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Professor Menachem Hanani

born: 1945 (Petah-Tikvah, Israel)

Laboratory of Experimental Surgery
Hadassah University Hospital
P.O. Box 12000
Mt. scopus, Jerusalem 91905
Email: hananim@cc.huji.ac.il
Ph: 02-584-4721
Fax: 02-582-3515

Education:

1968 B.Sc. in Chemistry and Physics, The Hebrew University

1970 M.Sc. in Physical Chemistry, The Hebrew University

1976 Ph.D. in Neurobiology, The Hebrew University


Appointments

1979- present, Head, Laboratory of Experimental Surgery, Hadassah University Hospital, Mount Scopus, Jerusalem.

1979- present, Dept. of Physiology, Hebrew University-Hadassah Medical School, Jerusalem.

1976 - 1978 Laboratory of Neurophysiology, NIH, Bethesda, MD, USA

July 1989-Sept. 1990 Ohio State University, Columbus, OH, USA

Main research interests

Mechanisms of chronic pain. The autonomic nervous system. Electrophysiology of enteric neurons. The role of glial cells in the nervous system. Physiology, pharmacology and morphology of the digestive tract in health and disease.

Sample of recent recent publications

Hanani, M., Francke, M., Härtig, W., Grosche, J., Reichenbach, A., and Pannicke, T. A patch clamp study of neurons and glial cells in isolated myenteric ganglia. Am. J. Physiol. 278:G645-G651, 2000.

Ermilov, L.G., Miller, S.M., Hanani, M., Schmalz, P.F. and Szurszewski, J.H. The three-dimensional structure of the guinea-pig inferior mesenteric and pelvic-hypogastric ganglia. Autonomic Neuroscience, 83:116-126, 2000.

Hanani, M. and Freund H.R. Interstitial cells of Cajal -- their role in pacing and signal transmission in the digestive system. Acta Physiol Scand. 170:177-190, 2000.

Hanani, M. and Brading, A.F. Electrical coupling among smooth muscle cells, is it universal? J. Basic Clin. Physiol. Pharmacol. 11:321-330, 2000.

Belzer, V., Kobilo, T., Rich A. and Hanani M. Intercellular Coupling among interstitial cells of Cajal. Cell Tissue Res. 307:15-21, 2002.

Rich, A., Hanani M., Ermilov, L.G., Malysz, J., Belzer, V., Szurszewski, J.H., Farrugia, G. Physiological study of interstitial cells of Cajal identified by vital staining. Neurogastroenetrol Motil. 14:189-196, 2002.

Nissan, A., Freund, H.R., and Hanani, M. Direct inhibitory effect of erythromycin on human alimentary tract smooth muscle. Am. J. Surgery 183:413-418, 2002.

Hanani M., Huang, T.Y., Cherkas P.S., Ledda, M., Pannese E. Glial cell plasticity in sensory ganglia induced by nerve damage. Neuroscience, 114:279-283, 2002.

Pannese, E., Ledda, M., Huang, T.Y., Cherkas, P.S., Hanani, M. Satellite cell reactions to axon injury of sensory ganglion neurons: increase in number of gap junctions and formation of bridges connecting previously separate perineuronal sheaths. Anat. Embryol., 206:337-347, 2003.

Reichenbach, A., Derouiche A., Grosche, J. and Hanani, M. Structural association of glia with the various specialized compartments of neurons. In: Hatton GI & Parpura V (eds), Neuron Glia Interactions, Kluwer Publishers, in press, 2003.

Hanani, M., Ledder, O., Yutkin, V., Abu-Dalu, R , Huang, T.Y., Härtig, W., Vannucchi, M.G. and Faussone-Pellegrini, M.S. Regeneration of myenteric plexus in the mouse colon after experimental denervation with benzalkonium chloride. J Comp. Neurol., in press, 2003.

Kobilo, T., Szurszewski, J.H., Farrugia, G., Hanani, M. Coupling and innervation patterns of interstitial cells of Cajal in the deep muscular plexus (ICC-DMP) of the guinea-pig. Neurogastroenterol. Motil., in press, 2003.

Weick, M., Cherkas, P.S., Härtig, W. , Pannicke, T., Uckermann, O., Bringmann, A., Tal, M., Reichenbach, A., and Hanani, M. P2 Receptors in satellite glial cells in trigeminal ganglia of mice. Neuroscience, in press, 2003.

Huang TY, Hanani M, Ledda M, De Palo S, Pannese E. Aging is associated with an increase in dye coupling and in gap junction number in satellite glial cells of murine dorsal root ganglia. Neuroscience 137:1185-1192, 2006.

Faussone-Pellegrini, M.S., Vannucchi, M.G., Ledder, O., Huang, T.Y., Hanani, M. Interstitial cells of Cajal plasticity. A study in the mouse colon. Cell Tiss Res 325:211-217, 2006.

Dublin, P., Hanani, M. Satellite Glial cells in Sensory Ganglia: their Possible Contribution to Inflammatory Pain. Brain Behav Immun 21:992-981, 2007.
104. The cholinergic properties of soy. Roeytenberg, A., Cohen, T., Freund, H.R., Hanani, M. Nutrition, 23:681-686, 2007.

Hanani M, Nissan A, Freund HR. Innervation of submucosal adipocytes in the human colon. Neurosci Lett. 428:7-10, 2007.

Thi, M.M., Spray, D.C., Hanani, M. Aquaporin-4 water channels in enteric neurons. J Neurosci Res, In press, 2007.

Hanani, M., Kushnir, R., Cherkas, P.S. Nerve damage or inflammation augment purinergic signaling in satellite glial cells in mouse sensory ganglia. Proceedings of the VIII European Meeting, Glial Cells in Health and Disease, London, 2007. Medimond Press, 83-86, 2007.

Badriyyah, M., Mazeh, H.., Brocke, S.,Osmanova, V., Freund, H.R.., Hanani, M. Prevention of lipopolysaccharide-induced intussusception in mice by the COX2 inhibitor rofecoxib. Ped. Surg. Int. In press, 2007.

Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: a calcium imaging study.
Kushnir R, Cherkas PS, Hanani M.
Neuropharmacology. 2011 Sep;61(4):739-46.

Functional study of endothelin B receptors in satellite glial cells in trigeminal ganglia.
Feldman-Goriachnik R, Hanani M.
Neuroreport. 2011 Jul 13;22(10):465-9.


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