Key Words: Pharmacokinetics (PK), PK-based design of drugs, antiepileptics, CNS drugs, chirality.
Pharmacokinetics and biopharmaceutics of existing and new drugs.
Pharmacokinetic-based design of new antiepileptics and CNS drugs.
Structure-pharmacokinetic-pharmacodynamic relationships (SPPR).
Pharmacokinetic evaluation of drug interactions, new drug delivery systems, prodrugs and controlled-release formulations.
Stereospecific pharmacokinetic and pharmacodynanmic analysis of chiral drugs
Various international pharmaceutical companies
NIH Epilepsy Branch
Prof. Rene H. Levy, Univ. of Washington, Seattle, USA
Prof. H. Steve White, Univ. of Utah, USA
Drs. Bert de Boer and Rob Voskyl, Leiden Univ.,Holland
Prof. Emilio Perucca, Univ. of Pavia, Italy
Prof. Richard Finell, Texas A&M Univ. ,USA
Pharmacokinetic (PK) analysis
PK-based synthesis and design
Analytical chemistry GC-MS, LC-MS, HPLC, GC
M Bialer, S Hadad, J Herzig, JSterling, D Lerner, M Shirvan. Derivatives of valproic acid amide and 2-valproenoic acid amides, methods of making and use thereof as anticonvulsant agent. U.S. Patnet No. 5,585,358 Issued 17.12.1996.
1. J Sterling, 1. Y Herzig, M Bialer, 1. A Haj-Yehia, B Yagen, . Derivatives of tetra methylcyclopropane. U.S. Patnet No. 5,880,157. Issued 9. 3.1999.
M Bialer, A Dagan, S Sussan. Anticonvulsant drugs and pharmaceutical compositions thereof. U.S. Patent No. 6,028,102. Issued 22.2.2000.
M Bialer, B Yagen, N Papo. Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation. U.S. Patent No. 6,323,365. Issued 27.11.01.
A Sintov, A Volosov, M Bialer, B Yagen. Pharmaceutical compositions containing low-melting waxes. U.S. Pat Applic Ser 09/743,260. Filing 1.1.01.