Menachem Hanani

Picture of Prof. Menachem Hanani

Menachem Hanani

Laboratory of Experimental Surgery
Hadassah Medical Center, Mt. Scopus, Jerusalem 91240 Hebrew University of Jerusalem
Phone: +972 2-584-4721, 972-54-4288308, Fax: +972 2-582-3515


Education

1968 B.Sc. in Chemistry and Physics, The Hebrew University 
1970 M.Sc. in Physical Chemistry, The Hebrew University 
1976 Ph.D. in Neurobiology, The Hebrew University

Appointments

1979- Present, Head, Laboratory of Experimental Surgery, Hadassah University Hospital, Mount Scopus, Jerusalem.
1979- Present, Dept. of  Medical Neurobiology, Hebrew University-Hadassah Medical School, Jerusalem.
1976 - 1978 Laboratory of Neurophysiology, NIH, Bethesda, MD, USA
July 1989-Sept. 1990 Ohio State University, Columbus, OH, USA
2004- Present. Professor, Hebrew University-Hadassah Medical School
2013- Present.  Guest Professor, College of Medicine, Nanchang University, Nanchang, China

Main research interests

Mechanisms of chronic pain. The autonomic nervous system, The role of glial cells in the nervous system. Neuron-glia interactions underlying chronic pain, Satellite glial cells, Physiology, pharmacology and morphology of the digestive tract in health and disease.

Selected recent publications

Hanani, M. Intercellular communication in sensory ganglia by purinergic receptors and  gap junctions: Implications for chronic pain. Brain Res.  1487:183-191, 2012.

Warwick, RA, Hanani, M. The contribution of satellite glial cells to chemotherapy-induced neuropathic pain. Europ. J. Pain. 17:571-580, 2013.

Blum E, Procacci P, Conte V, Hanani M.. Systemic inflammation alters satellite glial cell function and structure. A possible contribution to sickness behavior. Neuroscience 274:209-217, 2014.

Hanani M,  Blum E,  Liu S,  Peng L,   Liang S. Satellite glial cells in dorsal root ganglia are activated in streptozotocin-treated rodents. J. Cell. Molec. Med. 20: 2367-2371, 2014.

Feldman-Goriachnik R,  Belzer V, Hanani M. Systemic inflammation activates satellite glial cells in the mouse nodose ganglion and alters their functions. Glia 67:1296-1307, 2019. doi: 10.1002/glia.22881

Hanani M. Role of satellite glial cells in gastrointestinal pain. Front. Cell. Neurosci. 9:412, 2015 doi: 10.3389/fncel.2015.00412

Warwick RA, Hanani M. Involvement of aberrant calcium signalling in herpetic neuralgia. Exp Neurol. 277:10-18, 2016. doi: 10.1016/j.expneurol.2015.12.002.

Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, Dong X. Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain. Neuron. 91:1085-1896, 2016. doi: 10.1016/j.neuron.2016.07.044.

Hanstein R,   Hanani M,   Scemes E,   Spray  DC.  Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain. Scientific Reports  6:38266, 2016. doi: 10.1038/srep38266

Feldman-Goriachnik R,  Hanani M. The Effects of Endothelin-1 on Satellite Glial Cells in Peripheral Ganglia. Neuropeptides 63:37-42, 2017.  doi: 10.1016/j.npep.2017.03.002.

Spray DC, Iglesias R, Shraer N, Belzer V, Hanstein R, Hanani M. Electrical signaling between glia and neurons in trigeminal ganglia.  Glia 67:791-801, 2019. doi: 10.1002/glia.23554.

Belzer V, Hanani M. Nitric oxide as a messenger between neurons and satellite glial cells in dorsal root ganglia. Glia 67:1296–1307, 2019.  doi: 10.1002/glia.23603

Feldman-Goriachnik R , Hanani M.  The Effects of Sympathetic Nerve Damage on Satellite Glial Cells in the Mouse Superior Cervical Ganglion. Autonomic Neuroscience,  221:102584, 2019. doi: 10.1016/j.autneu.2019.102584

Hanani M,  Spray DC. Emerging importance of satellite glia in nervous system function and dysfunction. Nature Reviews Neurosci. 21(9):485-498, 2020. doi: 10.1038/s41583-020-0333-z

Hanani M,  Verkhratsky A. Satellite glial cells and astrocytes, a comparative review   Neurochemical Research. Neurochem Res. 46(10), 2525-2537, 2021. doi: 10.1007/s11064-021-03255-8

Feldman-Goriachnik R, Hanani M. How do neurons in sensory ganglia communicate with satellite glial cells? Brain Research. 1760: 147384, 2021.  doi: 10.1016/j.brainres.2021.147384.

Chen Z, Huang, Q,  Song, X,  Ford NC,  Zhang, C,  Xu, Q,  Lay M,  He SQ,  Dong X, Hanani M,  Guan Y. Purinergic signaling between neurons and satellite glial cells of mouse dorsal root ganglia modulates neuronal excitability in vivo. Pain, doi: 10.1097/j.pain.0000000000002556.

Cohen M, Feldman-Goriachnik R,  Hanani M. Satellite glial cells and neurons in trigeminal ganglia are altered in an itch model in mice. Cells, 11: 886, 2022. https://doi.org/10.3390/cells11050886

Feldman-Goriachnik, R, Blum E, Hanani M. Exercise Reduces Pain and Pathological Changes in Dorsal Root Ganglia Induced by Systemic Inflammation in Mice. Neuroscience Letters. 778: 136616, 2022, doi: 10.1016/j.neulet.2022.136616.