Menachem Hanani


Menachem Hanani

Laboratory of Experimental Surgery
Hadassah Medical Center
Hebrew University of Jerusalem, Mt. Scopus, Jerusalem 91905
Phone: +972 2-584-4721 , Fax: +972 2-582-3515


1968 B.Sc. in Chemistry and Physics, The Hebrew University 
1970 M.Sc. in Physical Chemistry, The Hebrew University 
1976 Ph.D. in Neurobiology, The Hebrew University


1979- Present, Head, Laboratory of Experimental Surgery, Hadassah University Hospital, Mount Scopus, Jerusalem.
1979- Present, Dept. of  Medical Neurobiology, Hebrew University-Hadassah Medical School, Jerusalem.
1976 - 1978 Laboratory of Neurophysiology, NIH, Bethesda, MD, USA
July 1989-Sept. 1990 Ohio State University, Columbus, OH, USA
2004- Present. Professor, Hebrew University-Hadassah Medical School
2011-Present. Visiting Professor, Albert Einstein College of Medicine, NY, USA
2013- Present.  Guest Professor, College of Medicine, Nanchang University, Nanchang, China

Main research interests

Mechanisms of chronic pain. The autonomic nervous system. Electrophysiology of enteric neurons. The role of glial cells in the nervous system. Physiology, pharmacology and morphology of the digestive tract in health and disease.

Sample of recent recent publications

Ledda, M., Blum, E., De Palo, S., Hanani, M. Augmentation in gap junction-mediated cell coupling in dorsal root ganglia following sciatic nerve neuritis in the mouse. Neuroscience.   164:1538-1545, 2009

Huang TY,  Belzer V,  Hanani M. Gap junctions in dorsal root ganglia: possible contribution tovisceral pain. Europ J Pain 14:49-57, 2010. 

Suadicani, S.O.,  Cherkas, P.S.,  Zuckerman, J., Smith, D.N., Spray, D.C., Hanani, M. Bidirectional calcium signaling between satellite glial cells and neurons in cultured mouse trigeminal ganglia. Neuron Glia Biology  6:43-51, 2010.

Hanani, M., Caspi, A. Belzer, V. Peripheral Inflammation Augments Gap Junction-Mediated Coupling among Satellite Glial Cells in Mouse Sympathetic Ganglia   Neuron Glia Biology 6:85-89, 2010.

Hanani, M. Satellite Glial Cells in Sympathetic and Parasympathetic Ganglia: In Search of Function. Brain Res Rev  64:304-327, 2010 

Hanstein, R.,  Basak, R.,  Zhao, J.B.,  Smith, D.N.,  Zuckerman, Y., Hanani, M., Spray,  D.C.,  Gulinello, M. Transient focal inflammation causes carbenoxolone-sensitive chronic pain in mice. Open Pain Journal 3:122-133, 2010.

Belzer V, Shraer N, Hanani M.  Phenotypic changes in satellite glial cells in cultured trigeminal ganglia. Neuron Glia Biology, 6, 237-243, 2010.

Kushnir R, Cherkas PS, Hanani M. Peipheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: a calcium imaging study.  Neuropharmacology. 61:739-46. 2011

Feldman-Goriachnik R, Hanani M. Functional study of endothelin B receptors in satellite glial cells in trigeminal ganglia.  Neuroreport. 2011;22(10):465-9.

Hanani M. Lucifer yellow - an angel rather than the Devil.  J. Cell. Mol. Med. 16, 22-31, 2012.


Burke, S., Hanani, M. The actions of hyperthermia on the autonomic nervous system: central and peripheral mechanisms and clinical implications. Autonomic Neurosci. 168:4-13, 2012.

Hanani, M. Intercellular communication in sensory ganglia by purinergic receptors and  gap junctions: Implications for chronic pain. Brain Res.  1487:183-191, 2012.

 Hanani,  M., Spray, D.C. Glial Cells in autonomic and sensory ganglia. In: Neuroglia; H. Kettenmann and B.R. Ransom, Eds. Oxford University Press, pp. 122-133, 2013.  

Warwick, RA, Hanani, M. The contribution of satellite glial cells to chemotherapy-induced neuropathic pain. Europ. J. Pain. 17:571-580, 2013.

Warwick, RA,  Ledgerwood CJ, Brenner T,  Hanani M. Satellite glial cells in dorsal root ganglia are activated in experimental autoimmune encephalomyelitis. Neurosci Lett. 569:59-62, 2014.

Blum E, Procacci P, Conte V, Hanani M.. Systemic inflammation alters satellite glial cell function and structure. A possible contribution to sickness behavior. Neuroscience 274:209-217, 2014.

Wagner L,  Warwick RA, Pannicke T,   Reichenbach A, Grosche A, Hanani M. Glutamate release from satellite glial cells of the murine trigeminal ganglion. Neuroscience Lett. 578:143-147, 2014.

Hanani M,  Blum E,  Liu S,  Peng L,   Liang S. Satellite glial cells in dorsal root ganglia are activated in streptozotocin-treated rodents. J. Cell. Molec. Med. 20: 2367-2371, 2014.

Poulsen JN,  Warwick RA,  Duroux MN,  Hanani M,  Gazerani P.. Oxaliplatin enhances gap junction-mediated coupling in cell cultures of mouse trigeminal ganglia. Exp. Cell Res. 336:94-99, 2015.

Feldman-Goriachnik R,  Belzer V, Hanani M. Systemic inflammation activates satellite glial cells in the mouse nodose ganglion and alters their functions. Glia 63:2121-2132, 2015.  

Hanani M. Role of satellite glial cells in gastrointestinal pain. Front Cell Neurosci. 9:412. 2015.

Warwick RA, Hanani M. Involvement of aberrant calcium signalling in herpetic neuralgia. Exp Neurol. 277:10-18, 2016.  

Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, Dong X. Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain. Neuron.  91:1085-96, 2016. 

Hanstein R,   Hanani M,   Scemes E,   Spray  DC.  Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain. Scientific Reports  6:38266, 2016.

Blum E, Procacci P, Conte V, Sartori P,  Hanani M. Long term effects of lipopolysaccharide on satellite glial cells in mouse dorsal root ganglia. Exp. Cell Res. 350: 236-241, 2017.