Citation:
Udasin, Ronald et al. “Photopharmacological Modulation Of Native Crac Channels Using Azoboronate Photoswitches”. Proc Natl Acad Sci U S A 119.13 (2022): e2118160119. Web.
Date Published:
2022 Mar 29Abstract:
SignificanceCalcium release-activated calcium (CRAC) channels play key roles in the regulation of cellular signaling, transcription, and migration. Here, we describe the design, chemical synthesis, and characterization of photoswitchable channel inhibitors that can be switched on and off depending on the wavelength of light used. We use the compounds to induce light-dependent modulation of channel activity and downstream gene expression in human immune cells. We further expand the usage of the compounds to control seeding of cancer cells in target tissue and regulation of response to noxious stimuli in vivo in mice.